Thursday, September 25, 2014

The Way Drugs Are Discovered Will Be Different in the Future


How hard it is to discover a drug?
There are only 1,453 drugs for all of the infectious diseases, cancers, cardiovascular diseases, skin conditions, neurodegenerative diseases and other ills the flesh is prone to, and that dates all the way back to 1827.

The Way Drugs Are Discovered Will Be Different in the Future

Before joining Washington University in St. Louis, Michael Kinch, PhD, was managing director of the Center for Molecular Discovery at Yale University.
“A few years ago, to motivate the team I gave them what’s called a Big Hairy Audacious Goal (a B-HAG),” Kinch says. 
The B-HAG was many-headed but one of the heads was to make a collection of all FDA-approved drugs. The idea was that the collection would serve as a screening library for drug repurposing.

Kinch thought the first step—pulling a list of drugs—would be easy; they’d go the FDA and get their list. But it turned out the FDA doesn’t have a complete list.

They had a running list of all prescribable drugs called the Orange Book. But “all prescribable drugs” isn’t quite the same thing as all the drugs that have ever been prescribed, since there are drugs that are no longer marketed or have been withdrawn because of concerns about safety or effectiveness.

“So what we did was compile a comprehensive list of drugs approved for use in the U.S.,” Kinch said. “By drugs, I mean the actual molecules that do the work, called new molecular entities (NMEs), as opposed to the fillers and the flavors.

We went all the way back to morphine, first sold by Merck in Germany in 1827 and shortly thereafter in the U.S., and worked our way forward to 2013, closing the database at the end of that year.

“How many do you think there were?” he asks.

There were 1,453—only 1,453 drugs for all of the infectious diseases, cancers, cardiovascular diseases, skin conditions, neurodegenerative diseases and other ills the flesh is heir to. “I thought it was rather a small number, myself,” Kinch said.

Answers to Your Questions About Alzheimer's and Dementia


Wednesday, August 20, 2014

How do you get a person with dementia to take their medication?


A reader searching Google using the following keywords

how do you get a person with dementia to take their medication

was directed to this article in the Alzheimer's Reading Room.

How do you get a person with dementia  to take their medication?

The problem, how to get a person suffering from Alzheimer's disease to take their medication?

How to Get an Alzheimer's Patient To Take Their Medication


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To learn more about Alzheimers and Dementia care visit the Alzheimer's Reading Room Intelligent Knowledge Base

Sunday, August 17, 2014

Where Can I Find Information About Alzheimer's Disease


The Alzheimer's Reading Room Knowledge Base contains more than 4,000 articles.


Where Can I Find Information About Alzheimer's Disease


Tuesday, July 1, 2014

Alzheimers Falling Over


A reader searching Google using the following keywords

Alzheimers Falling Over

was directed to this article




Saturday, June 28, 2014

Alzheimer Symptoms Smell


A reader searching Bing using the following keywords

Alzheimer Symptoms Smell

was directed to this article

smell


in the Alzheimer's Reading Room.

To learn more about Alzheimers care and Dementia care visit the Alzheimer's Reading Room Intelligent Knowledge Base

from Bob DeMarco

Wednesday, June 25, 2014

Dementia Info




From WellPoint


To learn more about Alzheimers and Dementia care visit the Alzheimer's Reading Room Intelligent Knowledge Base

Bob DeMarco
Alzheimer's Reading Room

Thursday, June 19, 2014

Alzheimer's Misdiagnosis


Patients with Alzheimer's and related dementia are frequently misdiagnosed.

A reader searching Bing using the following keyword search

alzheimers misdiagnosis

was directed to this article in the Alzheimer's Reading Room

Alzheimers

Another Misdiagnosis of Alzheimer's Another Miracle


The above article was ranked number one in this particular search of Bing.

You might also find this article of interest.

Atypical Form of Alzheimer’s Disease May be Present in a More Widespread Number of Patients, Mayo Clinic Says


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To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room Intelligent Knowledge Base